Tristan Rawling Selected Research

Antineoplastic Agents (Antineoplastics)

1/2023	Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids.
1/2022	Structure-Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism.
4/2021	Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite.
1/2020	Carbon Chain Length Modulates MDA-MB-231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl-Urea Fatty Acids.
1/2018	Carboxylate Analogues of Aryl-Urea-Substituted Fatty Acids That Target the Mitochondria in MDA-MB-231 Breast Cancer Cells to Promote Cell Death.
1/2015	Cytochrome P450-Mediated Biotransformation of Sorafenib and Its N-Oxide Metabolite: Implications for Cell Viability and Human Toxicity.
8/2012	Antiproliferative and antimigratory actions of synthetic long chain n-3 monounsaturated fatty acids in breast cancer cells that overexpress cyclooxygenase-2.

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Tristan Rawling Research Topics

Disease

19	Neoplasms (Cancer) 04/2024 - 07/2012
15	Breast Neoplasms (Breast Cancer) 05/2024 - 08/2012
8	Chronic Pain 01/2023 - 01/2018
6	Pain (Aches) 01/2022 - 01/2017
2	Triple Negative Breast Neoplasms 04/2024 - 12/2017
2	Hyperalgesia 01/2022 - 01/2020
2	Kidney Neoplasms (Kidney Cancer) 01/2019 - 07/2012
2	Leukemia 06/2015 - 08/2013
2	Carcinoma (Carcinomatosis) 01/2015 - 08/2013
1	Uveal melanoma 02/2024
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2023
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Acute Pain 01/2022
1	Neuralgia (Stump Neuralgia) 01/2022
1	Drug-Related Side Effects and Adverse Reactions 04/2021
1	Obesity 01/2021
1	Hypersensitivity (Allergy) 01/2020
1	Necrosis 01/2020
1	Renal Cell Carcinoma (Grawitz Tumor) 10/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Iron Overload 01/2019
1	Liver Diseases (Liver Disease) 03/2018
1	Liver Cirrhosis (Hepatic Cirrhosis) 03/2018
1	Skin Neoplasms (Skin Cancer) 06/2015

Drug/Important Bio-Agent (IBA)

12	Fatty Acids (Saturated Fatty Acids)IBA 01/2023 - 09/2014
8	LipidsIBA 04/2024 - 04/2014
8	Sorafenib (BAY 43-9006)FDA Link 12/2023 - 07/2012
7	Antineoplastic Agents (Antineoplastics)IBA 01/2023 - 08/2012
6	Glycine Plasma Membrane Transport ProteinsIBA 01/2022 - 01/2017
5	Urea (Carbamide)FDA LinkGeneric 01/2023 - 01/2018
5	Glycine (Aminoacetic Acid)FDA LinkGeneric 01/2022 - 01/2017
5	Palmitic Acid (Hexadecanoic Acid)IBA 01/2022 - 10/2017
4	AcidsIBA 01/2023 - 09/2014
4	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 10/2021 - 08/2012
3	Epoxy Compounds (Epoxides)IBA 10/2021 - 09/2014
3	Tyrosine Kinase InhibitorsIBA 04/2021 - 07/2012
2	Protons (Proton)IBA 01/2023 - 01/2022
2	Analgesics (Analgesic Drugs)IBA 01/2021 - 10/2019
2	Amino Acids FDA Link 10/2020 - 01/2019
2	OxidesIBA 01/2019 - 08/2013
2	Phosphotransferases (Kinase)IBA 01/2019 - 08/2013
2	EnzymesIBA 03/2018 - 06/2015
2	Adenosine Triphosphate (ATP)IBA 04/2014 - 08/2013
1	Cytotoxins (Cytolysins)IBA 05/2024
1	Drug CombinationsIBA 04/2024
1	Biomarkers (Surrogate Marker)IBA 02/2024
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 12/2023
1	CationsIBA 11/2023
1	SulfurIBA 01/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023
1	AnionsIBA 01/2023
1	Non-Narcotic Analgesics (Analgesics, Non Narcotic)IBA 01/2023
1	Freund's AdjuvantIBA 01/2022
1	Opiate AlkaloidsIBA 01/2022
1	Proteins (Proteins, Gene)FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	4- benzyloxy- 3,5- dimethoxy- N- (1- (dimethylaminocyclopently)methyl)benzamideIBA 01/2022
1	Lysine (L-Lysine)FDA Link 01/2022
1	Paclitaxel (Taxol)FDA LinkGeneric 04/2021
1	Insulin (Novolin)FDA Link 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Glycine Receptors (Glycine Receptor)IBA 10/2020
1	AmidesIBA 01/2020
1	CarbonIBA 01/2020
1	7-aminoactinomycin DIBA 01/2020
1	caryophylleneIBA 01/2020
1	Annexin A5IBA 01/2020
1	p38 Mitogen-Activated Protein KinasesIBA 03/2019
1	CyclinsIBA 03/2019
1	quinone (benzoquinone)IBA 01/2019
1	Levodopa (L Dopa)FDA LinkGeneric 01/2019
1	IronIBA 01/2019
1	QuinonesIBA 01/2019
1	Dopamine (Intropin)FDA LinkGeneric 01/2019
1	alpha-SynucleinIBA 01/2019
1	Dihydrotachysterol (AT 10)IBA 10/2018
1	cytochrome P-450 CYP2C subfamilyIBA 03/2018
1	Imatinib Mesylate (Gleevec)FDA Link 03/2018
1	BilirubinIBA 03/2018
1	Serum AlbuminIBA 03/2018
1	Cytochrome P-450 CYP3AIBA 03/2018
1	Ion Channels (Ion Channel)IBA 01/2018
1	17,18-epoxy-5,8,11,14-eicosatetraenoic acidIBA 12/2017
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 12/2017
1	CytochromesIBA 12/2017
1	AlkaloidsIBA 11/2017
1	Cardiolipins (Cardiolipin)IBA 10/2017
1	Lipoxygenase (Lipoxygenase-1)IBA 06/2015
1	EicosanoidsIBA 06/2015
1	Eicosapentaenoic AcidIBA 06/2015
1	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 06/2015
1	Phospholipids (Phosphatides)FDA LinkGeneric 06/2015
1	Membrane LipidsIBA 06/2015
1	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 06/2015
1	CeramidesIBA 06/2015

Therapy/Procedure

7	Therapeutics 02/2024 - 01/2018
6	Analgesia 01/2022 - 01/2017
1	Denervation 01/2019
1	Oral Administration 10/2018